We fund research to improve treatment for people with GI and HPB cancers. All BRIGHT’s medical Trustees are involved in research studies

Targeting Cancer

Dr Sharadah Essapen, Consultant Clinical Oncologist and  BRIGHT Trustee has been working with Professor Modjtahedi of Kingston University on a four-year research project exploring targeted treatments for colorectal cancer patients.

This project is investigating the use of biomarkers (a substance whose detection indicates a particular disease state) expressed on tumour cells, which could potentially lead to new anti-body based drugs targeted to the individual patient.

Identifying these biomarkers is important as it will help to prevent patients being given unnecessary treatment.

Professor Helmout Modjtahedi & Team, Kingston

Evaluating Colorectal Cancer Treatments

Following the purchase of the Papillon Machine (which delivers targeted low energy x-rays to early stage rectal cancers), BRIGHT is now funding the collection of valuable data on patients treated by Papillon, as well as patients receiving other colorectal treatments.

The aim of funding this ongoing data collection is to assess the effectiveness of Papillon treatment on patient-centred outcomes, such as survival and quality of life. BRIGHT’s aim is for this database to be used by all Papillon centres around the world.

Evaluating HPB Cancer Treatments

The outcomes for pancreatic and liver cancer surgery are collected on two dedicated databases. The hope  is that BRIGHT will support staff to enter patient data  so that the outcomes in terms of survival can be  understood and publicised. The table shows current outcome figures.

Professor Nariman Karanjia Consultant HPB Surgeon

Nariman Karanjia’s survival figures

Clinical

Dr Tony Dhillon, BRIGHT Trustee, Senior Lecturer and Consultant Medical Oncologist at the RSCH has recently obtained external funding for his research programme. BRIGHT has been proud to fund Dr Dhillon’s research  salary which has enabled him to develop world leading cancer trials. Dr Dhillon’s clinical trials investigate:

  • Whether immunotherapy can improve the outcomes for bowel cancer patients
  • Liver functioning following chemotherapy
  • How responsive certain cancers are to particular drug treatments

The findings of these studies have the potential  to change future treatments for colorectal cancer patients.

Dr Tony Dhillon, Consultant Medical Oncologist

Dr Tony Dhillon Consultant Medical Oncologist

Vectra Polaris Machine

Following the purchase of a Vectra Polaris machine by the Prostate Project in 2019, BRIGHT funded a dedicated technician who will oversee and operate the equipment.

The Vectra Polaris is a new class of Automated Quantitative Pathology Imaging System that can easily detect and measure up to 9 overlapping biomarkers within a single tissue section. This state of the art technology will provide in-depth analysis of interactions between immune and cancerous cells that was previously impossible. It is vital to the development of cancer immunotherapy, a revolutionary new form of treatment which artificially stimulates the immune system to treat cancer and will help transform cancer care in the UK. In addition, the new machine will provide a valuable service to Royal Surrey County Hospital Pathology Unit​.

Vectra Polaris machine

Eirini Martinou

I am carrying out my current PhD research under the supervision of Professor Karanjia and the Postgraduate Director Dr Lisiane Meira at University of Surrey. I am very grateful to BRIGHT for their contributions to funding my work.

My research is looking at whether certain genes called ‘HOX’ may be important in patients with colorectal liver metastases (colorectal cancer that has spread to the liver). HOX genes are genes responsible for organ development and several studies have shown that they play an important role in various types of cancers such as blood cancers and prostate cancers, however their role in colorectal cancer (especially when spread to the liver) has not been fully investigated to date.

I am exploring whether these HOX genes may play a role in colorectal cancer initiation and progression and therefore whether they may help in the development of more targeted treatment in the future. I am also looking at the relationship between these genes and overall survival, for example whether patients who over express these genes have worse survival outcomes in comparison with those who express these genes at a lesser extent.

I have produced preliminary results of my work and subsequently won the Thomas Vicary Prize at the Kent Surrey and Sussex surgical symposium (Thomas Vicary Prize); see more at https://www.ksssurgicalsymposium.com/

Eirini MartinouEirini Martinou, PhD Research Student

Publications

These are some of the research papers produced by the medical Trustees of BRIGHT

The human papillomavirus as a common pathogen in oropharyngeal, anal and cervical cancers.  2019  Download document (pdf)

Liver resection for colorectal cancer metastases involving the caudate.  October 2011   Download abstract

Survival and recurrence after neo-adjuvant chemotherapy and liver resection for colorectal metastases: a ten year study. August 2008 Download document (pdf)

 

Randomized clinical trial on enhanced recovery versus standard care following open liver resection.  July 2013    Download document (pdf)

‘Close shave’ in liver resection for colorectal liver metastases.  January 2009   Download abstract